How CBG Works and Uses of CBG

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Many people are aware of what cannabidiol (CBD) and tetrahydrocannabinol (THC) are, but are not aware of CBG. Cannabigerol (CBG) is another non-psychoactive cannabinoid that’s abundant in CBD cannabis strains. CBG interacts with cannabinoid receptors in your brain in a similar way to CBD.

CBG can help people manage their pain, fight inflammation, and impede the growth of cancerous cells. Recent research studies have also shown that CBG may also reduce the intraocular eye pressure that results from glaucoma. The CBG content in the cannabis plant comes in much lower concentrations than those of THC and CBD. Although these two compounds have overshadowed CBG for many years, scientific interest in cannabigerol has been growing steadily.

How CBG works

The mechanism of action of CBG isn’t very different from other cannabinoids. When taken ingested, the compound influences the ECS (endocannabinoid system) of its user. The ECS is a complex network of CB1 and CB2 receptors, which work alongside enzymes. When your body produces endocannabinoid compounds, they can bind with CB1 and CB2 receptors to help regulate physiological processes in your body, and keep your internal functions balanced.

While CB1 receptors are mostly found in your nervous system, CB2 receptors can exist anywhere in your body, including the immune system. A lot of endocannabinoids can react with these receptors. But, for the most part, AEA (anandamide) and 2-AG (2-arachidonoylglycerol) interact with CB1 and CB2 receptors.

Anandamide usually binds with CB1 and behaves like a neurotransmitter, affecting your cognitive functions and mood. 2-arachidonoylglycerol also binds with both CB1 and CB2 receptors, giving rise to anti-inflammatory effects. Plant-based cannabinoids such as THC and CBG can also interact with CB1 and CB2 receptors due to their similar chemistry.

For example, tetrahydrocannabinol (THC) can bind with these receptors and influence your thinking, and probably get you high. Although cannabidiol doesn’t directly bind with the above receptors, it can affect their mechanisms with other cannabinoids.

If you want to use CBG, it’s first necessary for you to understand how CBG works. Researchers have established that CBG mainly binds with CB2 receptors. Even in higher doses, cannabigerol can inhibit other compounds from interacting with CB1 receptors. CBG may or may not alter the effects of THC. The complex chain of reactions among different plant cannabinoids to create therapeutic effects in users is termed as the entourage effect.

The scientific community is only beginning to properly understand the entourage effect and its implications. Many cannabis users believe that the entourage effect works like magic. Therefore, people combine various cannabinoids to their advantage.

What are the uses of CBG?

Although researchers are yet to fully comprehend the health benefits of CBG, preliminary studies appear to show that it is a useful substance for treating various conditions. Here are some potential uses of CBG:

  • Anti-inflammatory

CBG shows anti-inflammatory properties; it could be used for treating chronic inflammation. Studies have shown that CBG could reduce inflammation in mice with inflammatory bowel diseases (IBD). It has not been confirmed whether CBG can effectively reduce inflammation in humans.

  • Neuroprotective effects

Apart from its anti-inflammatory properties, cannabigerol may also behave as an antioxidant, and possibly protect your nervous system against damage. Animal studies on the neuroprotective properties of CBG have yielded positive results. Cannabigerol could potentially improve motor neuron deficits.

  • Appetite stimulant

Based on animal studies in 2016, researchers believe that CBG could help people stimulate their appetite. In one study, rats that were given CBG were observed to have increased their overall food intake. No adverse effects were recorded, leading experts to think that CBG could help treat anorexia and cachexia.


Cannabigerol (CBG) is one of the new chemical compounds in cannabis plants. Present in low concentrations, CBG does not create a high in users. However, through its interactions with the endocannabinoid systems, CBG could deliver therapeutic results to consumers.


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